Tandem Labs

"Chromatographic improvements and overcoming matrix effects and carryover for a previously validated nine analyte LC/MS/MS assay using UPLC," Edmonda Cook, Min Meng and Patrick Bennett; Presented at the 2008 Bioanalytical, 9th Annual Land O'Lakes Conference, Merrimac, WI, July 2008. Click Here

"Immunogenicity assays using a novel ELISA format: comparison of sensitivity and drug tolerance to electrochemiluminescence (meso-scale discovery)," Robert J. Kubiak, et al; Presented at the 2008 AAPS National Biotechnology Conference, Toronto, Canada, June 2008. Click Here

"Overcoming challenges in development of LC/MS/MS methods for highly polar, low molecular weight, zwitterionic compounds: a quantitative assay for pregabalin," Ryan S. Adler, Spencer J. Carter, Troy Voelker; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Chiral chromatographic method development and validation for the quantitation of eszopiclone in human plasma using LC/MS/MS," Min Meng,  Lisa Rohde, and Patrick Bennett, as well as Vladimír Čápka, Astra Zeneca Pharmaceuticals LP; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Case studies of accurate measurement of small molecule drugs in various tissues: knowledge versus assumption," Marcele L. Barroso, Kristopher W. King, Chris Tran, Angela Shen and Xin Zhang; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Is MALDI-TOF MS ready for bioanalytical analysis?," Patrick Bennett, Qing Zhu, KC Van Horne, and Lily Li, as well as Yulin Huang, Vertex Pharmaceuticals; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Simultaneous quantitation of cytarabine and uracil arabinofuranoside in human plasma using LC-MS/MS," Laixin Wang, Yanhui Zhang, Roger Demers, Min Meng and Patrick Bennett; Presented at the 2008 ASMS Conference, Denver, CO, June 2008.

"Methodology of accelerating bioanalysis method development in drug discovery with LC/MS/MS," Ling Morgan, Guangyu Zhao, Xin Zhang, Lily Li; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Method development of LC-MS/MS analysis of aminoglycoside drugs: challenges and solutions," Angela (Qi) Shen, Ling Morgan, Marcele L. Barroso and Xin Zhang, as well as Tuyen Nguyen, Sepracor Inc.; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Non-ionization related matrix effects on quantitative determination of EC78 and its metabolites in human plasma using LC/MS/MS," Laixin Wang, Ming Meng, Brittney Weber, Troy Voelker, Jim Johnston, Luca Matassa, and Patrick K. Bennett from Tandem Labs as well as Samina Khan, Ron Huang, and Liyu Yang from Biogen Idec, San Diego, CA; Presented at the 2007 AAPS Annual Meeting, San Diego, CA, November 2007. Click Here

“A randomized, double-blind, dose-response study of fentanyl in combination with bupivacaine 0.5% 300 µg/kg for subarachnoid blockade in children,” Alejandro Nava-Ocampo, Qualia Clinical Services; Presented at the 2007 AAPS Annual Meeting, San Diego, CA, November 2007

“Quantitation of Endogenous Plasma Thymidine Using ¹³C Labeled Thymidine as Surrogate Analyte,” Min Meng and Patrick K. Bennett, et al, as well as Genentech, Inc. (South San Francisco, CA); Presented at the 2007 ASMS Conference, Indianapolis, IN, June 2007; Presented at the 2007 AAPS Annual Meeting, San Diego, CA, November 2007. Click Here

"Dealing with Assay Performance Problems (Investigation, Corrective Action and Preventive Action)," Luca Matassa; Speaking engagement at the 2007 BSAT/APA conference, Boston, MA, September 17, 2007. Presentation

“Challenges of Modifying an Existing Quantitative Assay: Adding a New Metabolite,” Patrick K. Bennett, Ryan Adler, et al, as well as Pfizer, Inc., PGRD Groton Laboratories (Groton, CT); Presented at the 2007 ASMS Conference, Indianapolis, IN, June 2007; Presented at the 2007 Bioanalytical, 8th Annual Land O'Lakes Conference, Merrimac, WI, July 2007. Click Here

"Minimizing matrix effects in the development of a method for the determination of salmeterol in human plasma by LC/MS/MS at low pg/mL concentration levels," Vladimír Čápka, Spencer J. Carter; Journal of Chromatography B June 2007; 856: 285–293. Click Here

“Focus on Method Selectivity: A Means to Reduce Matrix Effects and Increase Throughput and Ruggedness in Bioanalytical LC/MS/MS Applications,” Vladimír Čápka, et al; Presented at the 2007 ASMS Conference, Indianapolis, IN, June 2007. Click Here

“Quantitative Determination of Phlorizin in Human Plasma and Urine Using LC/MS/MS,” Robert Marquardt, et al, as well as the Department of Medicine, University of Colorado (Aurora, CO); Presented at the 2007 ASMS Conference, Indianapolis, IN, June 2007. Click Here

“Urea Increases Extraction Recovery and Assay Specificity for Drug Analysis in Human Breast Milk Using LC/MS/MS,” Laixin Wang, et al, as well as Immtech Pharmaceuticals, Inc. (Vernon Hills, IL); Presented at the 2007 ASMS Conference, Indianapolis, IN, June 2007. Click Here

“An Orthogonal Approach to Increasing Assay Ruggedness at Low Limits of Quantitation in LC/MS/MS Assays,” Spencer Carter, Vladimír Čápka, and Stephen Viccarone; Presented at the 2007 ASMS Conference, Indianapolis, IN, June 2007. Click Here

"Determination of Warfarin Enantiomers in Human Plasma Using LC/MS/MS in the Presence of Twelve Co-administered Drugs and Metabolites," Vladimír Čápka, Spencer J. Carter, and Stephen Viccarone; Presented at the AAPS Annual Meeting, San Antonio, TX, October 2006. Click Here

"Strategy for Conducting Equilibrium Dialysis of Plasma Samples and Subsequent LC-MS/MS Analysis of the Resultant Samples," Xiaohui (Sophia) Xu, Anne Rose, Timothy Eley, Mohammed Jemal, Stanley Howell, Timothy Olah, and Mark Arnold from Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb, Princeton, New Jersey; and John Ryan, Roger Demers, and Ed Brewer from Tandem Labs; Presented at the AAPS Annual Meeting, San Antonio, TX, October 2006. Click Here

"Variable Between and Within Species Ionization Matrix Effects Using Negative Ion ESI-LC/MS/MS," Patrick K. Bennett, Laixin Wang, Min Meng, and Brad Johnston; Presented at the ISSX 14th Annual Meeting, Rio Grande, Puerto Rico, October 2006. Click Here

"Evaluation of Alternative HT Intrinsic Clearance Measurement in Rat Liver Microsomes," M. David Ho, Yulin Huang, and Lily Li; Presented at the 9th Annual Symposium on Chemical & Pharmaceutical Structure Analysis (CPSA), Princeton, NJ, October 2006. Click Here

"Managing phospholipid-based matrix effects In bioanalysis," Patrick K. Bennett, Min Meng, and Vladimír Čápka; Presented at the 17th International Mass Spectrometry Conference, Prague, Czech Republic, August 2006. Click Here

"Quantitative determination of endogenous glucose in human nerve tissues and erythrocytes by turboionspray LC/MS/MS," Laixin Wang, Min Meng, KC Van Horne, and Patrick K. Bennett; Presented at the 2006 ASMS Conference, Seattle, WA, May 2006. Click Here

"Using supercritical fluid chromatography MS to alleviate the imprecision in bioanalysis resulting from the matrix effect of phospholipids," Patrick K. Bennett and Edward Brewer, as well as Mettler Toledo AutoChem (Newark, DE); Presented at the 2006 ASMS Conference, Seattle, WA, May 2006.

"A novel approach to quantify unbound cisplatin, carboplatin, and oxaliplatin in human plasma ultrafiltrate by measuring platinum-DDTC complex using LC/MS/MS," Min Meng, Ryan Kuntz, Al Fontanet, and Patrick K. Bennett; Presented at the 2006 ASMS Conference, Seattle, WA, May 2006. Click Here

"Non-intuitive strategies for minimizing matrix effects in development of ultrasensitive bioanalytical LC/MS/MS methods," Vladimír Čápka and Spencer J. Carter; Presented at the 2006 ASMS Conference, Seattle, WA, May 2006. Click Here

"Overcoming the interaction between fluticasone propionate and salmeterol in a combined validated assay by LC/MS/MS," Spencer J. Carter, Vladimír Čápka, Edward Brewer, and Patrick K. Bennett. Presented at the 2006 ASMS Conference, Seattle, WA, May 2006. Click Here

"Implication of phospholipids in significant matrix effects in negative ion ES-MS/MS," Tianyi Zhang, Min Meng, KC Van Horne, and Patrick K. Bennett; Presented at the 2005 AAPS Annual Meeting and Exposition, Nashville, TN, November 2005. Click Here

"Quantitative determination of endogenous sorbitol and fructose in human erythrocytes by atmospheric-pressure chemical ionization LC tandem mass spectrometry," H.R. Liang, T. Takagaki, R.L. Foltz, P. Bennett; Journal of Chromatography B, September 2005; 824(1-2):36-44. Click Here

"Quantitative determination of endogenous sorbitol and fructose in human nerve tissues by atmospheric-pressure chemical ionization liquid chromatography/tandem mass spectrometry," H.R. Liang, T. Takagaki, R.L. Foltz, P. Bennett; Rapid Communications in Mass Spectrometry, August 2005; 19(16):2284-2294. Click Here

"Elimination of endogenous interferences in analysis of polar compounds in biological fluids by HILIC and RP-HPLC in LC/MS/MS bioanalytical applications," Vladimir Capka, Patrick K. Bennett; Presented at the 2005 ASMS Conference, San Antonio, TX, May 2005. Click Here

"Identification of plasma components resulting in significant matrix effects in negative ion ESI-MS/MS," Patrick Bennett, Min Meng, KC Van Horne; Presented at the 2005 ASMS Conference, San Antonio, TX, May 2005. Click Here

"Quantitative API LC/MS/MS bioanalysis and matrix effects: considerations when changing source types," Luca C. Matassa, KC Van Horne, Christopher R. Bowerbank, Mark Anthony Reviea, Teresa Collazo, Shaundel Percey, Patrick K. Bennett; Presented at the 2005 ASMS Conference, San Antonio, TX, May 2005. Click Here

"Quantitative determination of dipyridamole in human plasma using liquid chromatography and electrospray ionization tandem mass spectrometry," Jerry Brisson, Christopher R. Bowerbank, Patrick K. Bennett. Tandem Labs and Otsuka Maryland Research Institute, Inc. Presented at the 2004 AAPS Annual Meeting and Exposition, Baltimore, Maryland, October 2004. Click Here

"Method development and validation for quantitative determination of methadone enantiomers in human plasma by liquid chromatography/tandem mass spectrometry," H.R. Liang, R.L. Foltz, M. Meng, P. Bennett; Journal of Chromatography B, July 2004; 806(2):191-198. Click Here

"Overcoming matrix effects resulting from biological phospholipids through selective extractions in quantitative LC/MS/MS," Patrick Bennett, Hairui Liang; Presented at the 52nd ASMS Conference on Mass Spectrometry, Nashville, TN, May 2004. Click Here

"LC/MS/MS assay using traditional GC/MS derivitization to allow small polar compound analysis," Brad I. Coppersmith, Edward A. Brewer, Jean Pineault;, Presented at the 52nd ASMS Conference on Mass Spectrometry, Nashville, TN, May 2004.Click Here

"Sensitive and selective LC/MS/MS method for determination of endogenous polyols in human nerve tissues," Hairui Liang, Rodger L. Foltz, Patrick Bennett; Presented at the 52nd ASMS Conference on Mass Spectrometry, Nashville, TN, May 2004. Click Here

"Investigation of analyte recoveries from a new sorbent designed to remove phospholipids and reduce associated matrix effects," KC Van Horne, Min Meng, Robert Marquardt, Patrick Bennett; Presented at the 52nd ASMS Conference on Mass Spectrometry, Nashville, TN, May 2004. Click Here

"Source for imprecision resulting from ionization suppression from strongly retained phospholipids and dioctyl phthalate," Min Meng, Patrick Bennett; Presented at the 52nd ASMS Conference on Mass Spectrometry, Nashville, TN, May 2004. Click Here

"Ionization enhancement in atmospheric pressure chemical ionization and suppression in electrospray ionization between target drugs and stable-isotope-labeled internal standards in quantitative liquid chromatography/tandem mass spectrometry," H. R. Liang, R. L. Foltz, M. Meng, P. Bennett; Rapid Communications in Mass Spectrometry, December 2003; 17(24):2815-2821. Click Here

"Identification of the major endogenous and persistent compounds in plasma, serum, and tissue that cause matrix effects with electrospray LC/MS techniques," Patrick Bennett, KC Van Horne; Presented at the 2003 AAPS Annual Meeting and Exposition, Salt Lake City, Utah, October 2003. Click Here

"Preventing matrix effects by using new sorbents to remove phospholipids from biological samples," KC Van Horne, Patrick Bennett; Presented at the 2003 AAPS Annual Meeting and Exposition, Salt Lake City, Utah, October 2003. Click Here

"Simple and rapid determination of carboplatin in human plasma ultrafiltrate using LC/MS/MS by direct injection coupled with post column addition," Min Meng, Sherry Liu, Patrick Bennett; Presented at the 2003 AAPS Annual Meeting and Exposition, Salt Lake City, Utah, October 2003. Click Here

"Ionization enhancement in APCI and suppression in ESI between target drugs and stable isotope-labeled internal standards in quantitative LC/MS and LC/MS/MS," Hairui Liang, Rodger L. Foltz, Min Meng, Pat Bennett; Presented at the ASMS Conference, Montreal, Canada, June 2003. Click Here

"Method development and validation for quantitative determination of methadone enantiomers in human plasma by liquid chromatography/tandem mass spectrometry (LC/MS/MS)," Hairui Liang, Min Meng, Pat Bennett, Rodger L. Foltz; Presented at the ASMS Conference, Montreal, Canada, June 2003. Click Here

"Development of a LC/MS assay for the quantification of levofloxacin and moxifloxacin in human plasma," Min Meng, Uma Robbie, Spencer Carter, Anna Akrami, Mari Heybroek, Xianrong Wei, Toni Peacock, Al Fontanet, Tonya Felix, Jerry H Brisson, Patrick Bennett; Tandem Labs and Otsuka Maryland Research Institute, Inc.; Presented at the 2002 AAPS Annual Meeting and Exposition, Toronto, Canada, November 2002.

"Overcoming imprecision resulting from water loss during the quantitation of moxifloxacin and levofloxacin in human plasma using atmospheric pressure ionization mass spectrometry," Spencer Carter, Min Meng, Mari Heybroek, and Patrick Bennett; Presented at the ASMS Conference, Orlando, FL, June 2002.

"Determination of NO-1886, an activator of lipoprotein lipase, and its metabolite in human plasma using SPE and LC/MS/MS," S.A. Reuschel, M. Meng, P. Bennett, T. Johnson, D. Mulford.; Tandem Labs and Tap Pharmaceutical Products, Inc. Presented at the 2001 AAPS Annual Meeting and Exposition, Denver, November 2001.

"Safety and clinical pharmacokinetics of DB289, a new orally bioavailable dication," P. Yeramian, M. Kruse, J. Allen, L. McChesney-Harris, K. Trendler, J. Hall, D.Boykin, R.Tidwell. Tandem Labs and Immtech International, Inc. Presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, 2001.

"Quantification of the prodrug DB289 and an active metabolite, DB75, in rat and monkey plasma using SPE, liquid chromatography and electrospray ionization tandem mass spectrometry," Kerri Trendler, James Allen, Ed Hall, Chad Stephens, Scott Reuschel, Gretchen Eagle, Patrick Bennett. Tandem Labs and Immtech International, Inc. Presented at the 2000 AAPS Annual Meeting and Exposition, Indianapolis, November 2000.

"Quantitative determination of a novel peptide, conantokin G, in biological matrices by liquid chromatography-tandem mass spectrometry," L. Jiang, R. Foltz, M. Morgan, R. McCabe. Tandem Labs and Cognetix, Inc. Presented at the 2000 AAPS Annual Meeting and Exposition, Indianapolis, October 2000. Click Here

"Rapid approach to resolve a matrix effect in a complex mixture of analytes," Patrick Bennett, Brad Coopersmith, Marc Browning, Jennifer Cragun, Edward Brewer, Jerry Brisson, Steven Bramer. Tandem Labs and Otsuka Maryland Research Institute, Inc. Presented at the ASMS Conference, Long Beach, CA, May 2000. Click Here

"Quantitative determination of a novel peptide, conantokin G, in rat plasma and serum by liquid chromatography-tandem mass spectrometry," L. Jiang, R. Foltz, M. Morgan, R. McCabe. Tandem Labs and Cognetix, Inc. Presented at the ASMS Conference, Long Beach, CA, May 2000.

"Determination of metformin in human plasma using liquid/liquid extraction and gas chromatography/mass spectrometry," S.A. Reuschel, M.E. Arnold, S. Percy, S. Liu, R.L. Foltz. Tandem Labs and Bristol-Myers Squibb. Presented at the 1999 AAPS Annual Meeting and Exposition, New Orleans, LO, November 1999.

"Quantitative determination of LSD and a major metabolite, 2-oxo-3-hydorxy-LSD, in human urine by solid-phase extraction and gas chromatography tandem mass spectrometry," S.A. Reuschel, S.E. Percey, S. Liu, D.M. Eades, and R.L. Foltz; J Anal Toxicol 1999; 23:306-11.

"Recent advances in chromatographic and mass spectrometric methods for determination of LSD and its metabolites in physiological specimens," S.A. Reuschel, D.M. Eades, and R.L. Foltz; J Chromtogr B 1999; 733:145-59.

"Quantitation of S-59 in human plasma by LC/MS/MS," Donald Eades, Scott Swickard, Rodger Foltz, John Maynard, Jason Hanchett, John Tessman. Tandem Labs and Cerus Corporation. Presented at the 1998 AAPS Annual Meeting and Exposition, San Francisco, CA, November 1998.

"A novel LC/MS/MS method for the determination of stereoisomeric lactones and their corresponding acids," Kerri Trendler, Marc Browning, David Vollmer, Brad Coopersmith, Rodger Foltz, Dara Hawthorn, Mohammed Jemal. Tandem Labs and Bristol-Myers Squibb. Presented at the 1998 AAPS Annual Meeting and Exposition, San Francisco, CA, November 1998.

"Applications of higher-order mass spectrometry," Donald Eades and Rodger Foltz; Presented at the Biomedical Mass Spectrometry Conference: Mass Spectrometry Society of Japan in Isei Shima, Hashikojima, Japan, July 9, 1998.

"Problems and solutions in quantitative determination of drugs and metabolites in physiological specimens by LC-MS/MS," R. Foltz and R. Edom; J Mass Spectrom Soc Jpn 1998; 48:235-40.

"Clinical pharmacokinetics of escalating I.V. doses of dexanabinol (HU-211), a neuroprotectant agent, in normal volunteers," M. Brewster, E. Pop, R. Foltz, S. Reuschel, W. Griffith, S. Amselem, A. Biegon. Tandem Labs and Pharmos Corporation. Int J Clin Pharmacol Therapeutics 1997; 35:361-5.

"Quantitative determination of ifetroban and its acylglucuronide metabolite in human plasma by liquid chromatography/tandem mass spectrometry (LC/MS/MS)," B. Coopersmith, K. Mayer, R. Foltz, D. Teitz, M. Jemal.; Tandem Labs and Bristol-Myers Squibb. Presented at the 1996 AAPS Annual Meeting and Exposition, Seattle, WA, October 1996.

"Quantitative determination of BMS-186318 in human plasma and urine by liquid chromatography/tandem mass spectrometry (LC/MS/MS)," C. Nelson, K. Mayer, D. Hawthorne, M. Jemal, R. Foltz. Tandem Labs and Bristol-Myers Squibb. Presented at the 1996 AAPS Annual Meeting and Exposition, Seattle, WA, October 1996.

"GC/MS analysis of body fluids for drugs of abuse," J.T. Cody and R.L. Foltz; In Forensic Applications of Mass Spectrometry, J. Yinon, ed., 1995; Baton Raton: CRC Press, 1-59.

"GC/MS/MS measurement of delta-9-tetrahydrocannabinol, naltrexone, and their active metabolites in plasma," C.C. Nelson, M.D. Fraser, J.K. Wilfahrt, R.L Foltz; Ther Drug Monitoring 1993; 15:557-62.

"Determination of lysergic acid diethylamide (LSD), iso-LSD, and N-demethyl-LSD in body fluids by gas chromatography/tandem mass spectrometry," C.C. Nelson and R.L. Foltz; Anal Chem 1992; 64:1578-85.

"Chromatographic and mass spectrometric methods for determination of lysergic acid diethylamide (LSD) and metabolites in body fluids," C.C. Nelson and R.L. Foltz; J Chromatography 1992; 580:97-109.